Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks
نویسندگان
چکیده
منابع مشابه
Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks
The impact of disulfide bonds on protein stability goes beyond simple equilibrium thermodynamics effects associated with the conformational entropy of the unfolded state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional association and strongly affect the rates of irreversible enzyme inactivation, highly relevant in biotechnological applications. While these kinet...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0070013